How Ketamine Therapy Can Rewire the Brain for Optimal Health

When the brain is being stressed over and over consistently, the synapses in the brain break down and cause depressive symptoms. Ketamine was mainly used as an anesthetic by many medical professionals, until recent studies have found that ketamine therapy has worked to help people with resistant treatment mental illness, such as depression or PTSD.

A study led by Conor Liston, a neuroscientist, and psychiatrist at Weill Cornell Medicine, has confirmed that synapse growth is involved and reveals how ketamine activates changes in the brain circuit function, improving depressive symptoms in as little as three hours. As ketamine therapy continues, the drug triggers the regrowth of synapses in the brain. This study opens new channels and questions on how to sustain antidepressant effects long term (Makin, 2019).

According to Translational Psychiatry, “a journal about the translational pathway between research in neuroscience and conceptually novel treatments:”

Researchers revealed that repeated ketamine treatments, as compared to a single injection, provoked an enhanced global efficiency in the brain and reduced neural path length. In other words, repeated ketamine treatments increased the synapse growth globally within the brain, and the pathways for neurotransmitters to get from one part of the brain to another has developed a shorter route (Gass, Becker, Reinwald, Cosa-Linan, Sack, Weber-Fahr, Vollmayr, & Sartorius, 2020).

Ketamine works differently than other existing antidepressant medications. It works on glutamate, which is the most common chemical messenger or neurotransmitter in the brain. Other antidepressants tend to affect other neurotransmitters, such as serotonin, norepinephrine, and dopamine. Glutamate changes certain synapses involved in underlying learning and memory, which is why ketamine is suspected to have neuroplasticity. Neuroplasticity is defined as the brain’s ability to change through growth and reorganization.

Ketamine is not a cure. Courses of doses may wear off within weeks to months. This is why the evidence is based from Gass et. al (2020) regarding repeated maintenance treatment is crucial until more studies bring light to other questions respecting ketamine therapy and how to sustain long-term effects.

Ketamine Wellness Centers is always here to help you or your loved one in your time of need. Since 2011, we have been here to give people hope and help. Feel free to visit our webpage at or give us a call at (855) KET-WELL and speak to a Patient Liaison today!

Ketamine Wellness Centers

Ketamine Wellness Center’s mission is to provide personalized, compassionate, high-quality care for people suffering from afflictions where Ketamine infusions have proven a successful treatment option (Depression, Chronic Pain, PTSD, OCD, Suicidality) while actively researching Ketamine’s efficacy to treat additional conditions. There is hope. There is help.

855-KET-WELL (1-855-538-9355)

844-KET-WELL (1-844-538-9355)



Chicago, Illinois
603 E Diehl Rd, Suite #139 Naperville, IL 60563

Dallas-Fort Worth, Texas
6144 Precinct Line Road, Suite 100 Hurst, TX 76054

Denver, Colorado
7261 S Broadway, Suite 10-L Littleton, CO 80122

Houston, Texas
12807 Haynes Rd. Building A, Unit 1 Houston, TX 77066

Jacksonville, Florida
3753-2 Cardinal Point Drive Jacksonville, FL 32257

Las Vegas, Nevada
7375 S. Pecos Rd. Suite 102 Las Vegas, NV 89120

Minneapolis-St Paul, Minnesota
11995 County Road 11, Suite 220 Burnsville, MN 55337

Mesa-Gilbert, Arizona
2451 E. Baseline Rd, Suite 300 Gilbert, AZ 85234

Phoenix, Arizona
3724 N 3rd. St. Suite 201 Phoenix, AZ 85012

Reno, Nevada
1895 Plumas St. #6 Reno, NV 89509

Salt Lake City, Utah
6087 S. Redwood Road STE. B Taylorsville, UT

Seattle, Washington
34709 9th Ave S. Suite-B 200 Federal Way, WA 98003

Tucson, Arizona
3130 N Swan Rd. Tucson, AZ 85712